External Beam Radiation Therapy in Treatment of Malignant Pheochromocytoma and Paraganglioma

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External Beam Radiation Therapy in Treatment of Malignant Pheochromocytoma and Paraganglioma

PURPOSE Pheochromocytomas (PCCs) are neuroendocrine tumors arising from the adrenal medulla or as paraganglioma (PGL) from extra-adrenal sites. While usually benign, a small fraction is malignant. Multi-modality therapy is used in treating malignant disease; however, little data exist on the role of external beam radiation therapy (EBRT). In this retrospective review, we assessed response to EB...

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External beam radiation therapy for advanced/unresectable malignant paraganglioma and pheochromocytoma

Purpose/Objectives To evaluate the role of external beam radiation therapy (EBRT) for treatment of malignant paraganglioma (PGL) and pheochromocytoma (PCC). Methods and materials A retrospective review was performed of all patients with malignant PGL/PCC treated with EBRT at our institution between 1973 and 2015. Local control (LC) per treated lesion and overall survival were estimated using ...

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Radiation-induced myocardial perfusion abnormalities in breast cancer patients following external beam radiation therapy

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DNA methylation analysis in malignant pheochromocytoma and paraganglioma☆

AIMS In recent years, aberrant DNA methylation of specific CpG sites has been detected in many types of malignant tumors, and the epigenetic regulation of promoter CpG sites is considered an important mechanism underlying carcinogenesis. This study aimed to establish the epigenetics of the malignant transformation of malignant pheochromocytoma (PCC) and paraganglioma (PGL) by performing a methy...

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ژورنال

عنوان ژورنال: Frontiers in Oncology

سال: 2014

ISSN: 2234-943X

DOI: 10.3389/fonc.2014.00166